Simple simulator illustrating how membrane potential is a function of its relative permeability to different ions (i.e. the activity of certain ion channels) and their transmembrane concentration gradients. Model includes both a simple GHK-based non-excitable membrane model and an excitable neuronal membrane model.
This interactive slide allows student to see how modulatory drugs can affect the binding and signal transduction of a neurotransmitter or hormone agonist at its target receptor.
Opioid Curves is, a simple interactive simulator illustrating the important pharmacodynamic factors influencing the physiological responses produced by administered opioid drugs.
Observe how various pharmacokinetic paramaters - e.g. e.g. bioavailability, volume of distribution (Vd) and clearance - influence plasma drug concentrations over time. (beta version)
A simple representation of the classic hippocampus model used for studying synaptic plasticity. Students can observe short term facilitation, LTP, association, and LTD in this model.
Interactive slide demonstrating the effects of different amino acid side chain chemical properties on ion channel ion selectivity.
Another whimsical app for illustrating the importance of body compartment pH in regulating the distribution of weak acid and weak base drugs.
An independent website that serves as a concise, graphic, and easily navigable database of site-directed mutagenesis results obtained for the ATP-gated P2X receptor family of ion channels. The objective of the site is in part to provide a simple teaching tool to help undergraduate and graduate students understand the basics of protein structure and function, which ois of vital importance to the field of molecular pharmacology and drug design.
Produced using Construct 2 (Scirra) with the “Rex_boids” behavior plugin. The plugin is, in turn, based on the flocking model developed by Craig Reynolds in 1986. In this app, I have also implemented a toggleable “view clearance” parameter similar to the one later proposed by Gary Flake (see The Computational Beauty of Nature: Computer Explorations of Fractals, Chaos, Complex Systems, and Adaptation), which biases the flock formation towards more bird-like V and echelon formations, rather than the fish-like school formations of Reynold’s original model.
A completely frivolous homage-in-progress to the glorious space video games of the 70's and 80's that I made for my kids. The images used are either cribbed from NASA's image library, vacation photos, or badly drawn by me. It probably doesn't belong on this particular website but what the hell.